ROLE OF HSP70 ATPASE DOMAIN INTRINSIC DYNAMICS AND SEQUENCE EVOLUTION IN ENABLING ITS FUNCTIONAL INTERACTIONS WITH NEFS.

Role of Hsp70 ATPase domain intrinsic dynamics and sequence evolution in enabling its functional interactions with NEFs.

Catalysis of ADP-ATP exchange by nucleotide exchange factors (NEFs) is central to the activity of Hsp70 molecular chaperones.Yet, the mechanism of interaction of this family of chaperones with NEFs is not well understood in the context of the sequence evolution and structural dynamics of Hsp70 ATPase domains.We studied the interactions of Hsp70 ATP

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Ethical and social implications of approaching death prediction in humans - when the biology of ageing meets existential issues

Abstract Background The discovery of biomarkers of ageing has led to the development of predictors of impending natural death and has paved the way for personalised estimation of the risk of death in the general population.This study intends to identify the ethical resources available to approach the idea of a long-lasting dying process and conside

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